PLoS One. l-Carnitine causes insomnia I've been taking l-Carnitine Fumarate in the evening and it's giving me serious insomnia. Tumori 2005;91(2):135-138. View abstract. View abstract. A randomized clinical trial. J Neurol.Sci 3-15-2004;218(1-2):103-108. Treatment with acetyl L-carnitine also appeared to protect these mice, suggesting that a similar preventative approach might work for depression-prone people. Loumbakis P, Anezinis P, Evangeliou A, and et al. Pola P, Tondi P, Dal Lago A, and et al. A randomized double blind versus placebo study. Speak with a healthcare provider to find out what dose might be best for a specific condition. 2010;21(7):580-588. Sotobatake I, Noda S, Hayashi H, and et al. View abstract. J Inherit.Metab Dis 2008;31(3):361-367. J Child Neurol 1997;12:461-3. 2010;68(5):743-752. Socha, P., Horvath, A., Vajro, P., Dziechciarz, P., Dhawan, A., and Szajewska, H. Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. Intern.Med 2010;49(16):1717-1725. Rossini, P. M., Marchionno, L., Gambi, D., Pirchio, M., Del Rosso, G., and Albertazzi, A. EMG changes in chronically dialyzed uraemic subjects undergoing d, 1- Carnitine treatment. 2010;58(5):551-565. Low levels of L-carnitine have been found to be associated with diabetic complications. Diabetologia 1997;40(1):A32. Zhang, J. M., Gu, X. F., Shao, X. H., Song, X. Q., Han, L. S., Ye, J., Qiu, W. J., Gao, X. L., Wang, Y., and Wang, M. X. 2010;16(5):420-422. L-Carnitine Side Effects: Common, Severe, Long Term - Drugs.com Some animal studies suggest that the acetyl form, acetyl-L-carnitine (ALCAR), may help prevent age-related mental decline and improve markers of learning (30, 31). Lebrun C, Alchaar H, Candito M, et al. Tempesta E, Troncon R, Janiri L, et al. Effect of L-carnitine supplement on semen parameters in men with idiopathic infertility. J Androl 2004;25(5):761-770. Am.J Kidney Dis 2007;50(5):803-812. Samimi M, Jamilian M, Ebrahimi FA, Rahimi M, Tajbakhsh B, Asemi Z. View abstract. A randomized controlled trial. Mol.Psychiatry 2012;17(3):290-314. Obes Rev. Kolker, S., Christensen, E., Leonard, J. V., Greenberg, C. R., Burlina, A. [L-carnitine: safe and effective for asthenozoospermia]. Evaluation of the therapeutic efficacy and tolerability of levocarnitine propionyl in the treatment of chronic obstructive arteriopathies of the lower extremities: a multicentre controlled study vs. placebo. El Beshlawy, A., Mohtar, G., Abd El, Ghafar E., Abd El Dayem, S. M., El Sayed, M. H., Aly, A. View abstract. Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. 7 Best Creatine Supplements for Women in 2023: A Dietitians Picks. Miwa, S. and Takikawa, O. L-Carnitine is a naturally occurring substance that the body needs for energy. Swart I, Rossouw J, Loots JM, and et al. Brevetti G, Diehm C, Lambert D, et al. Clin Nephrol 2003;59(1):24-30. 2005;45(6):343-351. Int J Gynaecol Obstet 2019;147(1):59-64. doi: 10.1002/ijgo.12902. Written by Cerner Multum. View abstract. Minerva Cardioangiol. Dev Med Child Neurol 1991;33:795-802. Malaguarnera, M., Bella, R., Vacante, M., Giordano, M., Malaguarnera, G., Gargante, M. P., Motta, M., Mistretta, A., Rampello, L., and Pennisi, G. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. Waldner, R., Laschan, C., Lohninger, A., Gessner, M., Tuchler, H., Huemer, M., Spiegel, W., and Karlic, H. Effects of doxorubicin-containing chemotherapy and a combination with L-carnitine on oxidative metabolism in patients with non-Hodgkin lymphoma. View abstract. View abstract. Wadzinski, J., Franks, R., Roane, D., and Bayard, M. Valproate-associated hyperammonemic encephalopathy. View abstract. Scand.J Clin Lab Invest 1985;45(2):179-184. Am.J Alzheimers.Dis Other Demen. 2013 Jul;27 Suppl 2:6-11. 2007;41(3):224-230. J Gastroenterol. Optom.Vis.Sci 2011;88(12):1439-1444. 2014 Jun;27(3):317-29. [The impact of L-carnitine administration on the serum level of myocardium injury markers in patients with acute carbon monoxide poisoning]. Lund, A. M., Joensen, F., Hougaard, D. M., Jensen, L. K., Christensen, E., Christensen, M., Norgaard-Petersen, B., Schwartz, M., and Skovby, F. Carnitine transporter and holocarboxylase synthetase deficiencies in The Faroe Islands. Bloomer, R. J., Farney, T. M., Trepanowski, J. F., McCarthy, C. G., Canale, R. E., and Schilling, B. K. Comparison of pre-workout nitric oxide stimulating dietary supplements on skeletal muscle oxygen saturation, blood nitrate/nitrite, lipid peroxidation, and upper body exercise performance in resistance trained men. Infusionsther.Klin.Ernahr. View abstract. Brevetti G, Chiariello M, Ferulano G, et al. 2002;4(1):61-66. Even though the chance of adverse side effects is slight, there are two things that we suggest when taking Coenzyme Q10. View abstract. 2014 Jul 21;14:88. 2011;270(1):76-84. Tentative evidence suggests L-carnitine supplements might increase your risk of atherosclerosis. View abstract. Laevo-acetylcarnitine (Nicetile registered) treatment of senile depression. Effects of L- and DL-carnitine on patients with impaired exercise tolerance. Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism. Clin J Pain 2008;24(8):731-733. [Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia]. J Inherit.Metab Dis 2008;31 Suppl 2:S219-S222. 1. Kidney Int 38 (1990): 904-11, 4. Angelova-Fischer I, Rippke F, Fischer TW, Neufang G, Zillikens D. A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne. Gorostiaga, E. M., Maurer, C. A., and Eclache, J. P. Decrease in respiratory quotient during exercise following L-carnitine supplementation. Korean J.Nutrition 2007;40(7):630-638. View abstract. Your body can produce L-carnitine out of the amino acids lysine and methionine. View abstract. In one study, people who took 3 grams every day for 21 days experienced no negative effects (57). Front Nutr 2021;8:748075. 2007;213(4):351-359. Arch.Pharm Res 2012;35(11):1945-1952. 2020;42(6):386-390. A randomized, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction. 2007;178(4 Pt 1):1398-1403. [Values of tandem mass spectrometry in etiologic diagnosis of cerebral developmental retardation]. Carnitine metabolism in early stages of Duchenne muscular dystrophy. 2-15-1981;96(3):263-270. L-Carnitine L-Tartrate (LCLT) is typically used for physical performance and power output. Oncologist 2010;15:200-11. Anxiety (feeling nervous and jittery). Spasov, A. By Steve Blechman BREAKING NEWS! View abstract. View abstract. Bianchi, G., Vitali, G., Caraceni, A., Ravaglia, S., Capri, G., Cundari, S., Zanna, C., and Gianni, L. Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-l-carnitine. Nephrologie 1998;19:171. Ricci, A., Caiati, C., Galantino, A., Scrutinio, D., Valentini, G., Chiddo, A., and Rizzon, P. [Acute effects of propionyl-L-carnitine on anomalies of parietal kinetics of the left ventricle induced by atrial pacing in patients with ischemic heart disease. Dalakas MC, Leon-Monzon ME, Bernardini I, et al. View abstract. Xie, H., Tang, S. Y., Li, H., Luo, X. H., Yuan, L. Q., Wang, D., and Liao, E. Y. L-carnitine protects against apoptosis of murine MC3T3-E1 osteoblastic cells. View abstract. 2012;13(2):285-293. van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. Am.J Kidney Dis 2008;52(5):962-971. Bjornsson, E. Hepatotoxicity associated with antiepileptic drugs. BMC Cardiovasc Disord. 2007;26(1):93-94. 2012;1:CD008427. Wu, Z. M., Lu, X., Wang, Y. W., Sun, J., Tao, J. W., Yin, F. H., and Cheng, H. J. You can get concerning Insomnia material over there! Zeitschrift fr Orthomolekulare Medizin 2009;7(3):22-24. View abstract. J Clin Lipidology 2012;6:150-158. Stuessi, C., Hofer, P., Meier, C., and Boutellier, U. L -Carnitine and the recovery from exhaustive endurance exercise: a randomised, double-blind, placebo-controlled trial. Diabetes Res.Clin Pract. Liu J, Head E, Kuratsune H, et al. Huang H, Song L, Zhang H, Zhang H, Zhang J, Zhao W. Influence of L-carnitine supplementation on serum lipid profile in hemodialysis patients: a systematic review and meta-analysis. Melegh, B., Kerner, J., Sandor, A., Vinceller, M., and Kispal, G. Effects of oral L-carnitine supplementation in low-birth-weight premature infants maintained on human milk. View abstract. View abstract. L-Carnitine Health benefits, dosage, safety, side-effects, and more It is used for weight loss and may have an impact on brain function. Filipek, P. A., Juranek, J., Nguyen, M. T., Cummings, C., and Gargus, J. J. Circulation 5-1-1996;93(9):1685-1689. Benefits of L-carnitine. Effects of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: a double-blind crossover field study. G.Ital.Nefrol. Background and aim: Clinical evidence which investigated the effects of l-carnitine, a vitamin-like substance, on weight loss had led to inconsistent results. Additional L-carnitine Reduced the Risk of Hospitalization in Patients with Overt Hepatic Encephalopathy on Rifaximin. View abstract. Physiologie. View abstract. View abstract. Am J Clin Nutr 1992;55(4):838-845. View abstract. Warfarin is used to slow blood clotting. J Eur Acad Dermatol Venereol 1999;13:205-9. Ann.Clin Lab Sci 2009;39(4):399-404. Chao, H. H., Chen, C. H., Liu, J. C., Lin, J. W., Wong, K. L., and Cheng, T. H. L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation. Eur.Urol. Castro-Gago M, Eiris-Punal J, Novo-Rodriguez MI, et al. Heringer, J., Boy, S. P., Ensenauer, R., Assmann, B., Zschocke, J., Harting, I., Lucke, T., Maier, E. M., Muhlhausen, C., Haege, G., Hoffmann, G. F., Burgard, P., and Kolker, S. Use of guidelines improves the neurological outcome in glutaric aciduria type I. Ann.Neurol. Z., Mandalidis, D., Taxildaris, K., and Vargemezis, V. Effects of L-carnitine on oxidative stress responses in patients with renal disease. What Is L-Carnitine? | L-Carnitine Benefits, Dosage & When To take? The equivalent dosage range for other forms of L-carnitine are as follows: 630-2,500mg (ALCAR), 1,000-4,000mg . L-Carnosine (-alanyl-L-histidine) is a dipeptide of the amino acids beta-alanine and histidine. Maccio, A., Madeddu, C., Gramignano, G., Mulas, C., Floris, C., Sanna, E., Cau, M. C., Panzone, F., and Mantovani, G. A randomized phase III clinical trial of a combined treatment for cachexia in patients with gynecological cancers: evaluating the impact on metabolic and inflammatory profiles and quality of life. Potential role of levocarnitine supplementation for treatment of chemotherapy-induced fatigue in non-anemic cancer patients. Carnitine supplementation in diphtheria. J Clin Rheumatol. View abstract. Ital J Neurol Sci 1981;2(3):255-262. J Pediatr 1986;109(6):984-988. View abstract. The main dietary sources of L-carnitine are meat, fish and some other animal products, such as milk. L-carnitine is technically FDA-approved for just one use: treating carnitine deficiency. 2000;2(2):189-193. View abstract. Carnitine deficiency disorders in children. It seemed to get me fairly wired. Am.J Kidney Dis 1999;34(4):678-687. Jpn Circ.J 1992;56(1):86-94. L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis. Effects of L-propionylcarnitine on ischemia-induced myocardial dysfunction in men with angina pectoris. J Am Coll Nutr. View abstract. Acta Med Scand 1982;212(3):115-120. Bolognesi, M., Amodio, P., Merkel, C., Godi, L., and Gatta, A. J Inherit.Metab Dis 2007;30(1):5-22. View abstract. Crentsil, V. Mechanistic contribution of carnitine deficiency to geriatric frailty. Insomnia (unable to sleep). Nutr Metab Cardiovasc.Dis. Minerva Anestesiol. Amelioration of the depression of HIV-infected subjects with L-acetyl carnitine therapy. HIV.Med. I was under the impression that ALCAR may cause insomnia but not other forms of carnitine. Effects of exercise intensity and altered substrate availability on cardiovascular and metabolic responses to exercise after oral carnitine supplementation in athletes. Kurul S, Dirik E, Iscan A. Serum carnitine levels during oxcarbazepine and carbamazepine monotherapies in children with epilepsy. Bernard, A., Rigault, C., Mazue, F., Le, Borgne F., and Demarquoy, J. L-carnitine supplementation and physical exercise restore age-associated decline in some mitochondrial functions in the rat. Int.J Cardiol. Kobulia B, Chapichadze Z Andriadze G Machavariani P. Effects of carnitine on 6-month incidence of mortality and heart failure in patients with acute myocardial infarction. Electromyogr.Clin Neurophysiol. Fujiwara, M., Nakano, T., Tamoto, S., Yamada, Y., Fukai, M., Takada, K., Ashida, H., Shimada, T., Ishihara, T., and Seki, I. J Postgrad Med 1999;45(2):38-41. 11. Geier, D. A., Kern, J. K., Davis, G., King, P. G., Adams, J. Van Oudheusden, L. J. and Scholte, H. R. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Jpn Heart J 1984;25(4):587-597. Call your doctor at once if you have: a seizure (convulsions). Diabetes Care 2005;28:89-94. . Lee BJ, Lin JS, Lin YC, Lin PT. Glycine Propionyl L-Carnitine (GPLC) is used to alleviate intermittent claudication and blood flow issues. View abstract. It can cause nausea, vomiting, stomach pain, weakness, and chest pain (angina). Effects of L-carnitine on oxidant/antioxidant status in acetic acid-induced colitis. Szymanski M, Wandtke T, Wasilow K, Andryszczyk M, Janicki R, Domaracki P. Comparison of 3- and 6-Month Outcomes of Combined Oral L-Carnitine Fumarate and Acetyl-L-Carnitine Therapy, Included in an Antioxidant Formulation, in Patients with Idiopathic Infertility.